Irf8 flox mouse

Author: rzyl

August undefined, 2024

http://www.dukecancerinstitute.org/transgenic-and-knockout-mouse WebThe Irf8 floxed targeted mutated mouse strain can be used to selectively ablate expression of IRF8 in any cell type in which a Cre recombinase gene is activated. This will permit the...

IRF8 Monoclonal Antibody (V3GYWCH), PE (12-9852-82)

WebFeb 1, 2011 · IRF8-null mice (IRF8 −/ ... Fig. 3A illustrates the strategy for conditional deletion of exon 2 of Irf8. The floxed and WT alleles were detected by PCR in genomic DNA . After crossing with CD19-Cre mice, the homozygous Irf8 f/f mice bearing the Cre gene exhibited a complete depletion of IRF8 protein in splenic B cells . In the BM ... WebSecukinumab (anti-IL-17A) (Cosentyx, AIN457) is a human IgG1κ monoclonal antibody that binds to the protein interleukin (IL)-17A, and is applied for the treatment of psoriasis, ankylosing spondylitis, and psoriatic arthritis. MW=147.9 kDa. Selleck's Secukinumab (anti-IL-17A) has been cited by 2 Publications the orphaned street picker

Marshall Fredericks - Wikipedia

WebProduct Specific Information. Description: The V3GYWCH monoclonal antibody reacts with human and mouse interferon regulatory factor 8 (IRF8; ICSBP). IRF8 is a 50 kDa transcription factor that plays a critical role in the development of dendritic cells (DC). Specifically, IRF8 is essential in the development and differentiation of plasmacytoid ... WebIRF8 Model Description These mice carry loxP sites flanking exon 3-6 of Irf8 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Irf8 gene. Related Strain (s) Irf8-KO Strain Name： C57BL/6JSmoc- Irf8em1Smoc WebUpon arrival, some Irf8 f mice were bred with B6.Cg-Tg(Sox2-cre)1Amc/J mice (Stock No. 008454) for germline removal of floxed exon 2. Offspring with pan deletion of floxed exon … the orphaned swimming pool

IFN Regulatory Factor 8 Restricts the Size of the Marginal Zone …

IRF8 suppresses pathological cardiac remodelling by inhibiting

WebJun 21, 2024 · IRI was induced in Irf8-deficient mice (Irf8 fl/fl Clec9a cre mice) and control mice (Irf8 fl/fl Clec9a wt mice). (A) mRNA expression of chemokine receptors C-C … WebMyeloid cell-specific IRF8 conditional knockout mice (IRF8flox/flox; Lyz2Cre/+) with a C57BL/6 background were generated by mating IRF8-flox mice (Feng et al. 2011) with Lyz2-Cre knock-in mice. The primers used for genotyping are shown in Supplementary Table S3. The genotyping results are shown in Supplementary Figure S4a. Harvesting of blood ... shropshire record officeWebInterferon regulatory factor 8 (Irf8) is a transcription factor that negatively regulates osteoclast differentiation and Irf8 global knockout (Irf8 -/-) mice have been shown to have … the orphaned spirit

"WebJan 1, 2014 · Here we show that IRF8 is downregulated in both mouse hearts and cardiomyocytes after hypertrophic stress treatment. Moreover, IRF8-deficient mice reveal an aggravated pressure overload-induced hypertrophic response, whereas the opposite effects occur in IRF8-overexpressing mice. " - Irf8 flox mouse

Irf8 flox mouse

IRF8 Transcription-Factor-Dependent Classical Dendritic Cells …

WebIrf8 cKO mice were generated by crossing Irf8 fl/fl mice with Csf1r cre mice, a monocyte/macrophage targeting Cre driver mice. ... Monocyte Subsets with High Osteoclastogenic Potential... WebJun 21, 2024 · We generated a mouse line with Irf8 -deficiency in Clec9a -expressing progenitors and hypothesized that Irf8 -deficiency would deplete cDC1s, which may promote a pro-inflammatory immune response and consequently drive AKI/AKD progression. Materials and Methods Animals

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Web014175 B6.Cg- Irf8 tm1.1Hm /J This Irf8 f floxed targeted mutation strain may be useful in generating conditional mutants for studying B cell differentiation, immunodeficiency … WebIRF8 is a transcriptional regulator that is essential for the differentiation and function of monocytes and macrophages and thus may be involved in the regulation of macrophage …

WebCreLysMFasflox/flox mice expressed Fas on B and T lym-phocytes isolated from peripheral blood (ref. 10 and data not shown) and the peritoneal cavity (Figure 1A). In contrast, Fas … WebMice in which the gene expressing B 2 receptor has been specifically deleted from the endothelium (B 2 flox/flox.Tie2 Cre) presented normal blood pressure readings compared …

WebEarly life and education. Fredericks was born of Scandinavian descent in Rock Island, Illinois, on January 31, 1908. [citation needed] His family moved to Florida for a short time and … WebFeb 14, 2014 · Here we show that IRF8 is downregulated in both mouse hearts and cardiomyocytes after hypertrophic stress treatment. Moreover, IRF8-deficient mice reveal an aggravated pressure...

WebIRF8 and IRF1 are transcriptional regulators that play critical roles in the development and function of myeloid cells, including activation of macrophages by proinflammatory signals …

WebThe Irf8 floxed targeted mutated mouse strain can be used to selectively ablate expression of IRF8 in any cell type in which a Cre recombinase gene is activated. This will permit the... shropshire real estate agentsWebFeb 11, 2024 · Mechanistically, loss of SENP3 increases interferon regulatory factor 8 (IRF8) SUMO3 modification at the K310 amino acid site, which upregulates expression of the nuclear factor of activated T cell c1 (NFATc1) and osteoclastogenesis. shropshire recoveryWebThe Transgenic and Knockout Mouse Shared Resource provides members of the DCI with comprehensive and user-friendly services for the production of custom designed, … shropshire records and research centreWebIrf8 −/ mice exhibited multiple deficiencies in myeloid and lym-phoid systems, including excessive generation of myeloid cells and diminished Th1 immune responses (37–39) … shropshire records office shrewsburyWebIRF8 (interferon regulatory factor 8) is a transcriptional activator or repressor. It specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes. … shropshire record society publicationsWebThe Kynu gene ( NCBI Reference Sequence: NM_027552.2 ; Ensembl: ENSMUSG00000026866 ) is located on mouse chromosome 2. Fourteen exons are identified , with the ATG start codon in exon 2 and the TAG stop codon in exon 14 (Transcript Kynu- 201: ENSMUST00000028223). Exon 3 will be selected as target site. Cas9 and gRNA will … the orphaned swimming pool analysisWebInterferon regulatory factor 8 (Irf8), also known as interferon consensus sequence-binding protein, is a component of the Irf transcription factor family. Irf8 is differentially expressed … the orphaned worlds